Biochem/physiol Actions

Primary TargetGalectin-1

Reversible: yes

General description

A dibenzofuran conjugated peptidomimetic (13-mer) that acts as an allosteric inhibitor of galectin-1 binding to cell surface glycans (IC₅₀ = 3 µM). Shown to reduce the proliferation of endothelial cells and reduce vessel density in murine tumor models.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Dings, R.P., et al, 2013, J. Pharm. Exp. Ther.344, 589.

Packaging

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sequence

SVQMKNva-[DBF]-IIVKLNA

Warning

Toxicity: Standard Handling (A)